This drug is commercially available in the market as Cialis, a yellow-colored and almond-shaped pill. The US Food and Drug Administration approved its use as a prescription medicine in 2003. Credit to the discovery of tadalafil goes to GlaxoSmithKline, erstwhile known as Glaxo Wellcome. The development, manufacture and commercialization of Cialis, however, were pursued by Eli Lilly as ED drug users were not Glaxo`s core market.
Some Glaxo executives must have been regretting their decision not to go into the market for penile dysfunction medication. In the US alone, it was estimated that between 10 and 20 million persons suffer from ED. The market for ED drugs has also been estimated at more than $3 billion. This lucrative market has developed despite the fact that insurance programs under state and federal agencies have removed coverage of ED medications. Private insurance companies still cover penile dysfunction treatment like tadalafil in their health programs.
Something must be amiss in the state and federal insurance programs` adverse policy on ED drugs, as definitely the disorder that these medications address is health-related requiring some government support. Erectile dysfunction is caused by many health-related problems such as diabetes, hypertension and other heart-related diseases. Fatigue, stress and anxiety are added factors that can cause or contribute to ED which can be efficiently and effectively be treated through drugs like the tadalafil-based Cialis.
The mechanics of action of this type of drug is simple. It inhibits an enzyme called PDE5 which is responsible for the destruction of the cyclic nucleotide cGMP in the body which is beneficial in smoothening of the tissues called corpus cavernosa along the length of the penis. With the inhibitor at work, blood flow to the penis is enhanced, resulting in a firmer and harder erection. Mere intake of tadalafil, however, will not necessarily produce penile erection. There has to be an outside sexual stimulus in order to achieve the desired erection of the penis to consummate a romantic encounter.
Having a fix of this ED drug Cialis is likewise relatively easy. Only 10 mg per day, taken prior to a sexual activity, is the starting dose recommended. This dose may either be reduced to 5 mg per day or increased to 20 mg daily, depending on the reaction of the user to the medicine. Possible tadalafil interactions with other drugs are likewise a consideration in the dose or use of the medication. For instance, persons taking medicine for heart-related diseases should first consult their family physician before using Cialis. The drugs` interaction could produce severe side effects. Read more on ED-related issues through the link here.
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